Ipamorelin

Ipamorelin

Ipamorelin

Ipamorelin is a synthetic growth hormone secretagogue that mimics the natural activity of ghrelin, the hunger hormone. Unlike older secretagogues such as GHRP-2 and GHRP-6, Ipamorelin offers a more selective stimulation of the growth hormone axis with minimal side effects on cortisol or prolactin levels. Its peptide structure (Glu-D-Ala-Lys-Trp-Ser-Met-Pro-His-Leu-Val-Asn) enables it to bind the ghrelin receptor (GHSR-1a) and trigger a cascade that releases endogenous growth hormone from the pituitary gland.

Clinical benefits of Ipamorelin include improved muscle protein synthesis, enhanced fat metabolism, accelerated tissue repair, and increased bone density. Athletes and bodybuilders often use it for lean mass gains while minimizing water retention. In older adults, Ipamorelin has shown promise in mitigating age-related sarcopenia and improving recovery after orthopedic surgery.

The peptide is typically administered via subcutaneous injection once or twice daily, with doses ranging from 200 µg to 500 µg per injection depending on the desired effect. Its half-life of approximately 30 minutes allows for flexible dosing schedules. Because Ipamorelin does not trigger significant appetite changes, it can be combined with calorie-controlled diets without compromising satiety.

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CJC-1295 No DAC & Ipamorelin – 5mg/5mg

This combination product merges the long-acting growth hormone-releasing peptide CJC-1295 (without a drug affinity component) and Ipamorelin into a single 10 mg vial. The synergy between CJC-1295’s sustained release of GH and Ipamorelin’s potent stimulation provides an extended, stable elevation of circulating growth hormone. Users report accelerated muscle hypertrophy, faster recovery from workouts, and improved sleep quality due to the combined anabolic signaling.

The formulation is designed for a 1:1 ratio (5 mg each), allowing precise dosing when mixed with sterile water or saline. The lack of DAC ensures that CJC-1295’s activity peaks rapidly, while Ipamorelin maintains the secretagogue effect over several hours. This pairing is popular among those who want to reduce injection frequency without sacrificing anabolic potency.

Tesamorelin & Ipamorelin Pack (BAC Included)

In this comprehensive pack, users receive both Tesamorelin—a recombinant growth hormone-releasing factor approved for HIV-associated lipodystrophy—and Ipamorelin. The inclusion of a BAC (Biological Activity Control) vial ensures batch consistency and potency verification.

Tesamorelin stimulates the release of growth hormone through a different receptor pathway than Ipamorelin, offering complementary mechanisms that enhance overall GH output. When combined, users often experience synergistic effects: greater lean body mass gains, reduced visceral fat, and improved metabolic markers such as insulin sensitivity. The pack is particularly useful for individuals who need both anti-lipodystrophy benefits and muscle anabolism.

Tesamorelin

Tesamorelin is a synthetic analog of growth hormone-releasing hormone (GHRH). Approved by regulatory agencies for the treatment of excess abdominal fat in HIV patients, it has also gained popularity off-label as a body-building aid. Its mechanism involves binding to GHRH receptors on pituitary somatotrophs, which leads to increased endogenous GH release and subsequent IGF-1 production.

Key advantages of Tesamorelin include its predictable pharmacokinetics (half-life ~30 minutes) and minimal impact on appetite or cortisol secretion. Regular injections (typically 2–3 times per week) can reduce visceral adiposity, lower triglyceride levels, and improve cardiovascular risk profiles. For athletes, the benefits translate into improved body composition and potentially faster recovery due to IGF-1 mediated protein synthesis.

cjc 1295 ipamorelin blend side effects-1295 DAC

CJC-1295 with a drug affinity component (DAC) is engineered for prolonged action in circulation. The DAC moiety binds albumin, extending the peptide’s half-life from hours to several days. This allows for once-weekly dosing while maintaining sustained growth hormone stimulation.

The DAC variant of CJC-1295 offers a robust IGF-1 response without the need for frequent injections. It is often paired with Ipamorelin or other secretagogues in advanced peptide stacks, providing continuous anabolic signaling that supports muscle repair, fat loss, and overall vitality. Users report improved sleep architecture and increased energy levels during prolonged use.

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The peptide functions by reorganizing actin filaments, thereby facilitating cellular movement and new blood vessel formation. In athletic contexts, TB500 is valued for rapid recovery from strains, sprains, and overuse injuries. Its therapeutic window is broad, with doses ranging from 2 µg/kg to 10 µg/kg per day, typically administered via subcutaneous or intramuscular injection.

TB500 (Frag 17-)

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The fragment’s smaller size allows for more efficient cellular uptake and reduced immunogenicity. While it does not possess the same robust angiogenic effect as TB500, Frag 17- remains a useful tool for studying wound healing dynamics and could complement longer peptides in therapeutic protocols.

Survodutide

Survodutide is a novel growth hormone secretagogue that has shown promise in early-phase studies for its ability to stimulate GH release with minimal side effects. Its unique structure targets the ghrelin receptor more selectively, offering an alternative for individuals who experience adverse reactions to older secretagogues.

Preliminary data indicate that Survodutide may improve lean body mass and reduce fat accumulation over a 12-week treatment period. Ongoing research focuses on optimizing dosing regimens and assessing long-term safety in diverse populations.

PT-141

PT-141, also known as Bremelanotide, is a melanocortin receptor agonist primarily recognized for its sexual stimulant properties. While not directly related to growth hormone secretion, it has gained attention among athletes and bodybuilders who seek enhanced libido and performance during training cycles.

The peptide’s mechanism involves binding to MC4 receptors in the central nervous system, which modulates sexual arousal pathways. Clinical trials have shown rapid onset of action (within 15–20 minutes) and a short duration of effect (~30 minutes). PT-141 is often included in peptide stacks for its ancillary benefits on motivation, confidence, and overall well-being.

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